Jason Bourne due to his natural physical ability as an agent, his tactical intelligence and I think above all his experience in combat against other agents.
Keep in mind that in the different Films he always faces some agent who, without saying what project they are from, the fact that Jason is already out of the CIA, indicates that these agents are from the new wave of projects like Outcome or LARX.
Another point is the difficulty that it presented for Aron to beat the LARX agent in Bourne Legacy, since from my point of view it went more badly than any confrontation that Jason usually has.